ACE-083

biologic · musculoskeletal · Intramuscular

ACE-083, a biologic. Locally acting follistatin-based fusion protein that binds myostatin, activins and GDF11. In a muscular dystrophy trial it increased muscle…

Locally acting follistatin-based fusion protein that binds myostatin, activins and GDF11. In a muscular dystrophy trial it increased muscle volume without consistent functional improvement.

PK: Local muscle effects should not be inferred from a generic systemic concentration curve. Human systemic PK remains to be reviewed. DOSE: PMID:35428982 studied local intramuscular injections of 240 mg per muscle every three weeks in a randomized FSHD trial. Muscle volume increased without consistent functional improvement; this is a trial protocol.

Sources: PMID:31388039, PMID:35428982