Aclidinium

pharmacological · nervous · respiratory · Inhaled

Aclidinium. Inhaled long-acting muscarinic antagonist (LAMA) — quaternary ammonium for minimal systemic exposure. Twice-daily dosing for COPD… Inhaled half-life 2 h.

Inhaled long-acting muscarinic antagonist (LAMA) — quaternary ammonium for minimal systemic exposure. Twice-daily dosing for COPD maintenance. Rapid plasma hydrolysis vs tiotropium's slow dissociation drives the dosing-frequency difference.