Agomelatine
Agomelatine. Atypical antidepressant — melatonin MT1/MT2 agonist + 5-HT2C antagonist. Resynchronizes circadian rhythm in depression with sleep… Oral half-life 1 h.
Atypical antidepressant — melatonin MT1/MT2 agonist + 5-HT2C antagonist. Resynchronizes circadian rhythm in depression with sleep architecture disruption. Hepatotoxicity warning requires LFT monitoring.
PK: half-life 0.96 h is verbatim and stands. F 0.04 is real drug pharmacology but has NO PubMed source — it was claiming support from a relative-bioequivalence study with no intravenous arm — so it is retained under an explicit label provenance rather than a citation it does not have. Dropping it was rejected because the resolver default of 0.9 would over-predict exposure more than twenty-fold for a drug whose first-pass extraction is near total. ka 1 /h and V 70 L dropped as unsourced; any volume recoverable from an oral area under the curve would be apparent and would need F pinned to 1.
Pharmacokinetics
- Oral — t½ 58 min · F 4%
Sources: PMID:28392509