Amlexanox

pharmacological · immune-hematologic · digestive · Oral

Amlexanox. Anti-inflammatory drug used for aphthous ulcers; inhibition of IKKε and TBK1 has also been investigated in human cells and clinical research.

Anti-inflammatory drug used for aphthous ulcers; inhibition of IKKε and TBK1 has also been investigated in human cells and clinical research.

PK: The cited paste study describes systemic exposure largely from gastrointestinal absorption after topical application. An oral-tablet PK review remains open. MASS: PubChem CID 2161, free compound, molecular weight 298.29 g/mol; salt forms may differ. DOSE FULL TEXT: PMID:28683283 administered 25 mg orally three times daily for two weeks then 50 mg three times daily for ten weeks in an open-label study, and 50 mg three times daily for 12 weeks in the randomized study. These are research protocols. Serum sampling did not establish a full concentration-time PK model.

Sources: PMID:28683283, PMID:9117755