Artemisinin
Artemisinin. Sesquiterpene lactone with endoperoxide bridge — heme-iron cleavage generates carbon-centered radicals that alkylate parasite proteins. First-line…
Sesquiterpene lactone with endoperoxide bridge — heme-iron cleavage generates carbon-centered radicals that alkylate parasite proteins. First-line antimalarial when paired with a longer-acting partner drug (artemisinin combination therapy / ACT). Resistance emergence in Southeast Asia is a public-health concern.
Sources: PMID:9604124, PMID:9443848, PMID:11678781, PMID:15676041