Baicalein

flavonoid · nervous · digestive · Oral

Baicalein, a flavonoid. Free-aglycone flavone; in root extracts it exists primarily as its 7-O-glucuronide baicalin, which is deconjugated by… Oral half-life 2.1 h.

Free-aglycone flavone; in root extracts it exists primarily as its 7-O-glucuronide baicalin, which is deconjugated by colonic microbial β-glucuronidase before baicalein is absorbed and re-conjugated in the enterocyte. Benzodiazepine-site positive allosteric modulator at GABA-A (α2/α3 subunits — mild anxiolytic without strong sedation), 12/15-lipoxygenase inhibitor, and senolytic when combined with tyrosine-kinase inhibitors (Scutellaria baicalensis Georgi is a core TCM calming herb). Poor oral F in aglycone form; extensive glucuronidation drives rapid plasma clearance.

Pharmacokinetics

• Oral — t½ 2.1 h · F 22%

Sources: PMID:25219601