BAM15

pharmacological · endocrine · renal · Oral

BAM15. Experimental mitochondrial protonophore that uncouples oxidative phosphorylation. Reported metabolic effects are preclinical and do not establish safety or…

Experimental mitochondrial protonophore that uncouples oxidative phosphorylation. Reported metabolic effects are preclinical and do not establish safety or efficacy in humans.

ROUTE: Oral dosing in the cited study was in mice. Absence of reported toxicity in a mouse experiment must not be extrapolated to human safety. MASS: PubChem CID 565708, free compound, molecular weight 340.29 g/mol; salt forms may differ. PK FULL TEXT: PMID:32409697 Results and Fig. 1c report mouse oral bioavailability 67% and plasma half-life 1.7 h (10 mg/kg PO versus 1 mg/kg IV). These values are retained as animal evidence and are not used for human concentration modeling.

Sources: PMID:24634817, PMID:32409697