Benfotiamine
Benfotiamine, a vitamin. Lipid-soluble thiamine prodrug. Hydrolysed by intestinal alkaline phosphatase to S-benzoylthiamine, which diffuses… Oral half-life 5 h.
Lipid-soluble thiamine prodrug. Hydrolysed by intestinal alkaline phosphatase to S-benzoylthiamine, which diffuses passively across membranes — bypasses the saturable SLC19A2/A3 transporter that limits thiamine HCl absorption at high doses. Achieves ~5× higher RBC/tissue thiamine than equivalent HCl. Activates transketolase, redirecting triose phosphates away from AGE precursors.
Pharmacokinetics
- Oral — t½ 5 h · F 60%
Related compounds
- Thiamine (B1) — synergistic
Sources: PMID:24399744