Biotin
Biotin, a vitamin. Covalently attached to the four mammalian carboxylases (pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA… Oral half-life 2 h.
Covalently attached to the four mammalian carboxylases (pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase) via holocarboxylase synthetase. Carries CO₂ during carboxylation reactions central to gluconeogenesis, fatty-acid synthesis, and amino-acid catabolism. Produced by gut microbiota — deficiency rare outside of raw-egg-white consumption (avidin binding) or biotinidase deficiency.
PK: THE STORED VOLUME WAS THE SOLVER DEFAULT WEARING A CITATION. 35 L is exactly 0.5 L/kg at the seventy-kilogram reference — the value resolvePk substitutes when the field is ABSENT — and this record cited abstract states no volume at all. Removing it is NUMERICALLY A NO-OP, since the resolver now supplies the identical number; what changes is that the record stops asserting a measurement it does not have, and the defaulted-volume lint begins counting it as the open gap it is. This is the batch-11 finding running backwards: there a deletion silently became a default, here a default had silently become a datum.
Pharmacokinetics
- Oral — t½ 2 h · F 100%
Sources: PMID:10075337