Boron
Boron, a mineral. Modulates SHBG and free testosterone; supports bone metabolism. Oral half-life 21 h.
Modulates SHBG and free testosterone; supports bone metabolism.
PK: Jansen 1984 (PMID:6732506), 8 volunteers, 562-611 mg boric acid IV, verbatim "t1/2 beta 21.0 +/- 4.9 h" with 98.7% urinary recovery; Schou 1984 (PMID:6595986) confirms 21 h orally in 7 men. ka, V and F were dropped 2026-09-06 as unsourced - that paper fits a three-compartment model with volumes in L/kg, so the stored single V 40 L restated it rather than quoting it, and oral absorption is quotable only as a 93.9% urinary recovery (PMID:6537937), which is not F. CAVEAT: the 21 h curve describes a BOLUS. Chronic intake is homeostatically buffered - Hunt 1997 (PMID:9062533) verbatim "a 9.0-fold increase in dietary boron but yielded only a 1.5-fold increase in plasma boron concentrations" - so this model will over-predict the excursion from a 3-10 mg/day supplement. Boron-DRUG and neutron-capture literature (acoziborole, BPA/BSH at ~25 ppm blood boron, ~300x dietary levels) is a different exposure and must never be merged here.
Pharmacokinetics
- Oral — t½ 21 h
Sources: PMID:25063690, PMID:10050928, PMID:6732506, PMID:6595986, PMID:6537937, PMID:9062533