Brexpiprazole
Brexpiprazole. Atypical antipsychotic — D2 + 5-HT1A partial agonist + 5-HT2A antagonist. Lower akathisia + activation than aripiprazole.… Oral half-life 3.8 d.
Atypical antipsychotic — D2 + 5-HT1A partial agonist + 5-HT2A antagonist. Lower akathisia + activation than aripiprazole. Approved for schizophrenia + adjunct in MDD + Alzheimer-related agitation (2023).
PK: ka 0.4 CONTRADICTED ITS OWN CITATION AND DUPLICATED THIS RECORD keo. The abstract states "The median tmax and the mean elimination half-life of brexpiprazole were 4-5 and 52-92 hours"; ka 0.4 with the stored half-life predicts a peak at 10.09 h, more than double the published 4-5 h. It is also byte-identical to the stored keo_per_h of 0.4 - the one-source-number-in-two-fields shape - and matches the placeholder that the same authoring wave used on eluxadoline, efavirenz, velpatasvir and doxepin. Removed rather than replaced, because reproducing the published Tmax would take a number nobody measured. V 240 IS A RANGE MIDPOINT: the full-text table gives V/F by dose arm as 307.8, 178.4 and 175.7, and 240 is none of them but is the midpoint of their span; the column is explicitly V/F while F 0.95 sits beside it, so F divides twice, costing about 5% because F is near 1. t-half 91 is the 1 MG SUBGROUP value, the lowest and least clinically relevant arm, where the 4 mg therapeutic arm measured 70.6 h. F 0.95 appears nowhere in the paper - a grep of the full text for bioavail returns nothing. All three are retained as label-grade rather than deleted, because the alternatives are a default and a midpoint. NO CROSS-DRUG TRANSPLANT WITH ARIPIPRAZOLE: all five fields differ, checked pairwise. PK: THE ABSENT ABSORPTION RATE IS ACQUITTED, WHICH IS WORTH RECORDING BECAUSE ITS NEIGHBOURS WERE NOT. This record has no ka, so the solver substitutes 1.0/h and renders a peak at 4.9 h — and its own citation states "tmax and the mean elimination half-life of brexpiprazole were 4-5 and 52-92" hours, so the DEFAULT FALLS INSIDE THE PUBLISHED RANGE. Nothing is authored: storing 1.0/h would assert a measurement where a coincidence is the honest description, and the value the solver already uses is correct.
Pharmacokinetics
- Oral — t½ 3.8 d · F 95% · Vd 240 L
Sources: PMID:28750151, PMID:31847007, PMID:24947465, PMID:33685346