Capsaicin

alkaloid · nervous · Transdermal · Oral

Capsaicin, an alkaloid. TRPV1 agonist — initial activation produces burning sensation; chronic exposure desensitizes nociceptors → topical… Transdermal half-life 24 h.

TRPV1 agonist — initial activation produces burning sensation; chronic exposure desensitizes nociceptors → topical analgesia for neuropathic pain (post-herpetic, diabetic neuropathy). Oral capsicum used for thermogenic / metabolic supplementation; modest effect.