Cannabinol

alkaloid · nervous · Inhaled · Oral

Cannabinol, an alkaloid. Oxidative degradation product of THC that accumulates in aged cannabis. A weak partial agonist at CB1 with notably… Inhaled half-life 43 h.

Oxidative degradation product of THC that accumulates in aged cannabis. A weak partial agonist at CB1 with notably higher relative affinity for CB2 than CB1; only mildly psychoactive vs THC. Marketed as a sleep aid, though controlled human sedation data are thin.

PubChem CID 2543. No verbatim CBN CB1 Ki and no abstract-verbatim half-life (see AUTHORING_GAPS).

Pharmacokinetics

• Inhaled — t½ 43 h · F 39% · Vd 3500 L

Sources: PMID:8819477