Cefepime
Cefepime. Fourth-generation cephalosporin — extended gram-negative coverage including Pseudomonas while retaining gram-positive activity.… Intramuscular half-life 2 h.
Fourth-generation cephalosporin — extended gram-negative coverage including Pseudomonas while retaining gram-positive activity. Empiric therapy for febrile neutropenia + healthcare-associated infections. Neurotoxicity (altered mental status, myoclonus) at high doses or renal failure.
PK: THE TRIAGE FLAGGED THIS RECORD TWICE AND BOTH FLAGS ARE FALSE POSITIVES, which is worth recording as clearly as a defect. It has NO ORAL PARAMETERS ANYWHERE — the absorption rate it was flagged for sits on the INTRAMUSCULAR route, a genuine approved route where an absorption rate is correct. And the identical half-life across routes is PHYSIOLOGICALLY REQUIRED here: cefepime is over eighty percent renally excreted unchanged with a verbatim "absolute bioavailability after intramuscular dose was 100%", so the two terminal half-lives must coincide. The intravenous clearance also passes, at 5.55 L/h against a verbatim range of 4.66 to 6.55. Only the intravenous half-life moves, to the value its own citation actually states — that abstract says "about 2.2 h" in young subjects and "about 3 h" in the elderly, and 2 appears in neither. Two smaller provenance gaps are recorded rather than patched: the volume is a computed midpoint of "Vss ranged from 0.21 to 0.24 liter/kg", and the intramuscular row volume is the intravenous number copied across, filed under an abstract that states no volume. The intramuscular absorption rate is a disclosed Tmax inversion of a midpoint of "mean peak times were 1.0-1.6 hours".
Pharmacokinetics
- IV — t½ 2.2 h · F 100% · Vd 16 L
- Intramuscular — t½ 2 h · F 100% · ka 1.44 h⁻¹ · Vd 16 L
Sources: PMID:1416818