Cefuroxime
Cefuroxime. Second-generation cephalosporin β-lactam — better gram-negative + β-lactamase stability than first-generation. Oral axetil prodrug +… Oral half-life 1.3 h.
Second-generation cephalosporin β-lactam — better gram-negative + β-lactamase stability than first-generation. Oral axetil prodrug + IV form. Common for acute otitis media + bronchitis + Lyme disease (early).
PK: all seven stored values were unsupported — the citation was a RELATIVE bioequivalence study, a design that cannot yield an absolute bioavailability, and the stored 1.5 h was its median Tmax IN HOURS. Re-sourced per parameter: oral F 0.35 fasted from Williams 1984 (PMID:6706890) against an intravenous reference, oral half-life 1.30 h from PMID:9017772, and the intravenous row from PMID:17589665, verbatim "elimination half-life: 1.8 h" and "0.19, 0.25, and 0.22 L/kg" (0.22 x 70 = 15 L, not the stored 35 L). TWO MOLECULES SHARE THIS RECORD: the oral product is cefuroxime AXETIL, an ester never detected intact in blood (PMID:6703686), and the intravenous one is cefuroxime sodium. Disposition is shared after de-esterification; absorption belongs to the ester alone, and the stored mw 424.39 is the free acid rather than either. Oral F is also food-dependent, 0.35 fasted against 0.45 fed. ka 0.9 /h dropped; that paper models absorption as apparent zero order.
Pharmacokinetics
- Oral — t½ 1.3 h · F 35% · Vd 15 L
- IV — t½ 1.8 h · F 100% · Vd 15 L
Sources: PMID:14696789, PMID:6706890, PMID:9017772, PMID:17589665, PMID:6703686