Chlorthalidone
Chlorthalidone. Thiazide-like diuretic — inhibits Na+/Cl- cotransporter (NCC) in distal convoluted tubule like HCTZ but with much longer… Oral half-life 44 h.
Thiazide-like diuretic — inhibits Na+/Cl- cotransporter (NCC) in distal convoluted tubule like HCTZ but with much longer half-life (~50h). ALLHAT and SHEP outcome data showed lower CV mortality vs HCTZ in some analyses; preferred over HCTZ in some hypertension guidelines.
PK: the best citation in this batch. F 0.64 is verbatim and stands, and the half-life is corrected 44 -> 44.1 h, the figure its paper states. But 44.1 h is the ORAL apparent value: the same crossover gives 36.5 h after a two-hour infusion, so it is not a disposition half-life and an intravenous row would have to carry 36.5. V 280 L is dropped as unsourced AND as conceptually unsafe — erythrocyte concentrations run 50 to 100 times plasma (PMID:649750) and plasma must be separated immediately or the measured concentration falls by more than half, so any plasma-referenced volume for this drug is a matrix artefact. The same study reports separate red-cell half-lives of 46.4 and 52.7 h. ka 0.7 /h dropped, probably a collision with the bioavailability estimates 0.67 and 0.72 that the abstract does contain.
Pharmacokinetics
- Oral — t½ 44.1 h · F 64%
Sources: PMID:971715, PMID:421727, PMID:649750