Chondroitin Sulfate

metabolite · musculoskeletal · immune-hematologic · Oral

Chondroitin Sulfate, a metabolite. Sulfated GAG of alternating glucuronic acid + N-acetylgalactosamine. Major cartilage matrix component. Oral CS… Oral half-life 15 h.

Sulfated GAG of alternating glucuronic acid + N-acetylgalactosamine. Major cartilage matrix component. Oral CS → small fragments absorbed (~10% F) → proposed to accumulate in synovium + inhibit IL-1β-driven MMP + aggrecanase activity. Modest symptomatic OA benefit in meta-analyses; structural disease modification debatable. EU Rx in some countries.

Pharmacokinetics

• Oral — t½ 15 h · F 10% · ka 1.91 h⁻¹

Related compounds

• Glucosamine — synergistic

Sources: PMID:12359162