Cisplatin

pharmacological · respiratory · renal · reproductive · IV

Cisplatin. Platinum-based DNA crosslinker — covalently binds N7 of guanine forming intra- and inter-strand adducts that block DNA replication.… IV half-life 3.3 d.

Platinum-based DNA crosslinker — covalently binds N7 of guanine forming intra- and inter-strand adducts that block DNA replication. Backbone of testicular, lung, head-and-neck, ovarian regimens. Nephrotoxicity, ototoxicity, severe nausea — pre-medication with antiemetics + IV hydration mandatory.