CJC-1295 (DAC)

peptide · endocrine · Subcutaneous

CJC-1295 (DAC), a peptide. Mod-GRF(1-29) with a N-terminal maleimidopropionyl lysine 'drug-affinity complex' (DAC) that covalently binds… Subcutaneous half-life 7 d.

Mod-GRF(1-29) with a N-terminal maleimidopropionyl lysine 'drug-affinity complex' (DAC) that covalently binds serum albumin via cysteine-34. Albumin binding extends plasma t½ to ~7 days — a 'constant GHRH tone' rather than pulsatile. Elevates GH + IGF-1 at steady state, possibly at cost of pituitary tachyphylaxis.

PK: Teichman 2006 (PMID:16352683), healthy adults, SC ascending doses, verbatim "The estimated half-life of CJC-1295 was 5.8-8.1 d" = 139-194 h. The stored 168 h (7 days) is the MIDPOINT of that stated range, kept because no scalar exists in any source and the range is quoted here so the spread is visible. This record models the DAC form (albumin-conjugated), which is what that paper studies; the unconjugated peptide is the separate mod-grf-1-29 record. ka 0.02 /h and V 7 L dropped 2026-09-06 — both are registry-wide defaults appearing in no abstract, V 7 L being plasma volume shared across 13 unrelated compounds.

Pharmacokinetics

Related compounds

Sources: PMID:16352683