Clofibrate
Clofibrate. First-generation fibrate (PPAR-α agonist) that activates lipoprotein lipase and lowers serum triglycerides + LDL. Largely supplanted by gemfibrozil and…
First-generation fibrate (PPAR-α agonist) that activates lipoprotein lipase and lowers serum triglycerides + LDL. Largely supplanted by gemfibrozil and fenofibrate due to a 1978 WHO trial showing increased non-cardiovascular mortality. Highly protein-bound (~96-97%) — clinically relevant as a warfarin plasma-binding displacer.
Related compounds
- Warfarin — major
Sources: PMID:480183