Clomipramine
Clomipramine. TCA with strongest serotonergic activity in the class — first-line TCA for OCD. Active demethyl-clomipramine metabolite contributes… Oral half-life 32 h.
TCA with strongest serotonergic activity in the class — first-line TCA for OCD. Active demethyl-clomipramine metabolite contributes NE reuptake inhibition. Same anticholinergic burden as other TCAs.
PK: REAL PMID, ZERO CONTENT - the citation states exactly one quantity and it is none of the four stored. PMID:8181196 gives only "The total median clearance of clomipramine was 99 L.hr-1", and because it is a single oral dose with no intravenous reference that figure is necessarily CL/F, not CL. The only human review carrying numbers CONTRADICTS all three stored values: "reduces oral bioavailability to less than 62 percent" is an inequality rather than 0.50, "(volume of distribution 9-25 L/kg)" is a range whose midpoint is not the stored 15.7 L/kg, and "a plasma half-life of 20-24 hours" puts the stored 32 h OUTSIDE it, with PMID:11185671 independently implying about 23 h. The values are kept and declared LABEL-GRADE rather than replaced with a range midpoint, which is itself a named defect class. ka 0.5 is removed: it predicts a peak at 6.56 h against a label Tmax of 2-6 h, outside the range, and is the same placeholder seen across this authoring wave. MY ANALYTE SUSPICION WAS WRONG - these are parent values, not desmethylclomipramine, whose half-life is about 69 h; the metabolite trap is real but confined to fu, where the note already documents it. The keo of 1.0 models a 42-minute equilibration for a drug whose antiobsessional effect emerges over WEEKS - a model-class mismatch rather than an imprecise rate.
Pharmacokinetics
- Oral — t½ 32 h · F 50% · Vd 1100 L
Sources: PMID:8181196, PMID:9537821, PMID:32608144, PMID:2197816, PMID:11185671