Clopidogrel

pharmacological · digestive · immune-hematologic · Oral

Clopidogrel. Thienopyridine antiplatelet prodrug — CYP2C19-mediated activation to thiol metabolite that irreversibly blocks platelet P2Y12 ADP receptor. CYP2C19 poor…

Thienopyridine antiplatelet prodrug — CYP2C19-mediated activation to thiol metabolite that irreversibly blocks platelet P2Y12 ADP receptor. CYP2C19 poor metabolizers + PPI co-administration reduce activation, lowering antiplatelet effect (clinically meaningful with omeprazole/esomeprazole; less with pantoprazole).

Sources: PMID:10440419, PMID:23016453, PMID:19948947