CoQ10
CoQ10, a terpenoid. Electron-transport-chain mobile carrier between Complex I/II and Complex III. Endogenously synthesised through the mevalonate… Oral half-life 33 h.
Electron-transport-chain mobile carrier between Complex I/II and Complex III. Endogenously synthesised through the mevalonate pathway (the same pathway statins inhibit — rationale for CoQ10 in statin-induced myopathy). Also a lipid-phase antioxidant, regenerated from ubiquinone to ubiquinol by cellular redox enzymes.
Pharmacokinetics
- Oral — t½ 33 h · F 10% · ka 0.25 h⁻¹ · Vd 17.5 L
Related compounds
- Atorvastatin / statins — caution
- Warfarin — caution
- PQQ — synergistic
Sources: PMID:16919858, PMID:15911722