Curcumin

polyphenol · immune-hematologic · Oral

Curcumin, a polyphenol. Inhibits nfkb signaling, arachidonic acid cascade COX-2, 5-LOX, and STAT3 — broad anti-inflammatory profile. Anti-oxidant… Oral half-life 6 h.

Inhibits NF-κB signaling, Arachidonic acid cascade COX-2, 5-LOX, and STAT3 — broad anti-inflammatory profile. Anti-oxidant via direct ROS scavenging + Nrf2 / Keap1 antioxidant response Nrf2 activation. Extensively glucuronidated + sulfated in the gut / liver — circulating aglycone is minimal without a bioavailability enhancer (Piperine inhibits glucuronidation). Most clinical effects at supplemental doses are modest; symptomatic OA improvement is the best-established endpoint.

Pharmacokinetics

• Oral — t½ 6 h · F 2% · ka 0.4 h⁻¹ · Vd 210 L

Related compounds

• Piperine — synergistic

Sources: PMID:9619120