Diisopropylamine dichloroacetate
Diisopropylamine dichloroacetate. Defined diisopropylamine salt of dichloroacetic acid, distinct from sodium dichloroacetate. Investigated as a pyruvate dehydrogenase…
Defined diisopropylamine salt of dichloroacetic acid, distinct from sodium dichloroacetate. Investigated as a pyruvate dehydrogenase kinase inhibitor, including PDK4 in an influenza mouse model; historically described as a vasodilator. These findings do not establish clinical efficacy for metabolic disease.
IDENTITY: PubChem CID 12617 identifies the 1:1 acid/amine compound C8H17Cl2NO2, molecular weight 230.13 g/mol. This salt has its own record; DCA remains an alias of dichloroacetate. ROUTE: PMID:24865588 directly reports oral administration in mice; this does not establish a human oral regimen. DOSE: PMID:15727691 compared 60 and 120 mg/day for eight weeks in NAFLD, with no placebo group. The abstract does not specify a per-administration dose or route; daily totals are retained as study context only. No conversion to sodium dichloroacetate doses or attribution of all effects to one ion is asserted.
Sources: PMID:10545828, PMID:24865588, PMID:15727691, PMID:3215480