Dermorphin
Dermorphin, a peptide. Potent mu-opioid receptor agonist originally isolated from amphibian skin. Opioid effects can include respiratory depression; human…
Potent mu-opioid receptor agonist originally isolated from amphibian skin. Opioid effects can include respiratory depression; human experimental findings do not establish a safe therapeutic regimen.
PK: The human study assessed a nociceptive reflex, not a plasma half-life. Its naloxone findings concern reversal of that measured reflex and must not be generalized to overdose treatment.
Sources: PMID:2543911, PMID:3697765, PMID:7195758