Desmopressin
Desmopressin, a peptide. Synthetic vasopressin (V2-selective) analog — antidiuretic via renal collecting-duct V2R but minimal V1 vasopressor… Oral half-life 3 h.
Synthetic vasopressin (V2-selective) analog — antidiuretic via renal collecting-duct V2R but minimal V1 vasopressor effect. Used for central diabetes insipidus, nocturnal enuresis, von Willebrand factor release in mild type-1 vWD (acute hemostasis).
PK: the half-life is an IV value — Rembratt 2004 (PMID:15197520) verbatim "terminal half-life, which was 3.1 h at night and 2.8 h in the daytime", corroborated at "2.97 +/- 0.24" h by Callreus 1998 (PMID:9868744) — and is carried on the other two routes as an assumption, since neither cited paper reports a route-specific half-life. Oral F 0.0008 is verbatim, "The bioavailability was 0.08%", and describes the TABLET; it is fragile as a point estimate because oral concentrations exceeded the assay limit in only about half the samples. V 16 L dropped 2026-09-06 as unsourced — the best human figure is a steady-state volume of 373 mL/kg, about 26 L (PMID:9868744) — along with the ka values on both extravascular routes. CAVEAT: the intranasal F of 0.08 is specific to AV002/SER120, an emulsified microdose spray with a permeation enhancer; a conventional desmopressin nasal spray is nearer 3.4% (PMID:8435898).
Pharmacokinetics
- Intranasal — t½ 3 h · F 8%
- Oral — t½ 3 h · F 0%
- IV — t½ 3 h · F 100%
Sources: PMID:31037429, PMID:15197520, PMID:10780976, PMID:9868744, PMID:8435898