Desvenlafaxine
Desvenlafaxine. SNRI — active O-desmethyl metabolite of venlafaxine. Bypasses CYP2D6 conversion → more consistent levels in CYP2D6 poor metabolizers. Stronger NE…
SNRI — active O-desmethyl metabolite of venlafaxine. Bypasses CYP2D6 conversion → more consistent levels in CYP2D6 poor metabolizers. Stronger NE component at therapeutic doses than venlafaxine.
PK REMOVED, AND THE REASON IS DELIBERATELY NOT uncharacterized. Desvenlafaxine is thoroughly characterised — in its label and registration dossier. What is missing is INDEXING: every candidate abstract reports ratios, percentage changes or subgroup contrasts and no absolute parameter. Its source_pmid was a NARRATIVE REVIEW, which is a contract violation independent of the numbers, and that review states only "t((1/2)) values of 9 to 15 hours" — the stored 11 is neither endpoint nor the midpoint 12 — and "reaches T(max) in 7 to 8 hours", from which the stored ka 0.25 was back-derived, since it solves to a 7.37 h peak. V 250 and F 0.8 are label figures. NO TRANSPLANT WITH VENLAFAXINE: the two records were compared field by field from both sides and share no value. This is the first use of the label-only reason, added for exactly this shape; tagging it uncharacterized would tell a future reader something false about the drug.
Sources: PMID:19698900, PMID:29228473, PMID:23623756