Dextroamphetamine
Dextroamphetamine, a stimulant. Releases dopamine + norepinephrine via TAAR1 activation and reversal of DAT/NET vesicular transporters. Pure… Oral half-life 10 h.
Releases dopamine + norepinephrine via TAAR1 activation and reversal of DAT/NET vesicular transporters. Pure d-isomer is more CNS-selective (vs racemic MAS); narrower peripheral sympathetic profile than l-amphetamine.
F 0.9 REMOVED as an R6 stored default. PMID:28936175 compares oral D-amphetamine with oral lisdexamfetamine and states no bioavailability; both arms being oral, no absolute F is derivable from it. Numerically a no-op against the 0.9 default. ABSORPTION-RATE PROVENANCE: this value was derived by inverting the one-compartment peak-time relation in 2026-05-26-wave25-ka-from-tmax.ts, whose header claimed every peak time was verbatim from a primary human study. ALL FORTY-FOUR ENTRIES HAVE NOW BEEN CHECKED AND TWENTY-EIGHT FAIL. This one fails because the number is verbatim but belongs to the RACEMIC amphetamine arm of that study, not to dexamfetamine. It is DISCLOSED RATHER THAN DELETED: a midpoint of a narrow range is usually inside the true spread, and removing it would fall back on the solver default of 1.0 per hour, which is worse for most of these records.
Pharmacokinetics
- Oral — t½ 10 h · ka 1.2 h⁻¹ · Vd 210 L
Sources: PMID:28936175, PMID:31809216