DMT

alkaloid · nervous · Inhaled · IV · Oral

DMT, an alkaloid. Tryptamine 5-HT2A/2C agonist; also sigma-1 and TAAR1 activity. Rapidly metabolised by MAO-A → inactive indole-3-acetic acid… Inhaled half-life 0.2 h.

Tryptamine 5-HT2A/2C agonist; also sigma-1 and TAAR1 activity. Rapidly metabolised by MAO-A → inactive indole-3-acetic acid (this is why oral requires MAOI potentiation as in ayahuasca). Endogenous production from tryptophan in small amounts has been characterised but in-vivo physiological role is unresolved.

Pharmacokinetics

• Inhaled — t½ 9 min

Sources: PMID:8297216