Donepezil

nootropic · nervous · digestive · Oral

Donepezil, a nootropic. Reversible centrally-active acetylcholinesterase inhibitor — raises CNS ACh. FDA-approved for all stages of Alzheimer's… Oral half-life 2.9 d.

Reversible centrally-active acetylcholinesterase inhibitor — raises CNS ACh. FDA-approved for all stages of Alzheimer's disease. Dose-dependent GI side effects (nausea, diarrhea) from peripheral cholinergic activity.

Pharmacokinetics

• Oral — t½ 2.9 d · F 100% · ka 0.46 h⁻¹ · Vd 840 L

Sources: PMID:9839768