Dorzolamide
Dorzolamide. Topical carbonic anhydrase II inhibitor — reduces aqueous humor production by ciliary epithelium. Often combined with timolol.… Transdermal half-life 4 h.
Topical carbonic anhydrase II inhibitor — reduces aqueous humor production by ciliary epithelium. Often combined with timolol. Sulfonamide moiety → cross-allergenicity caveat with sulfa-allergic patients (though clinically rare).
Sources: PMID:9029437