Doxepin (low-dose for sleep)

sleep · nervous · Oral

Doxepin (low-dose for sleep), a sleep compound. At low doses (3–6 mg) acts as a selective histamine H1 antagonist with minimal anticholinergic /… Oral half-life 15 h.

At low doses (3–6 mg) acts as a selective histamine H1 antagonist with minimal anticholinergic / antiadrenergic activity — sleep-maintenance hypnotic. Higher antidepressant doses (75–300 mg) lose the H1 selectivity.

Pharmacokinetics

• Oral — t½ 15.3 h · F 29% · Vd 11930 L

Sources: PMID:12162857