Doxycycline

pharmacological · integumentary · Oral · IV

Doxycycline. Tetracycline — binds bacterial 30S ribosome blocking aminoacyl-tRNA. Used for CAP atypicals, rickettsial infections, acne, malaria… Oral half-life 17 h.

Tetracycline — binds bacterial 30S ribosome blocking aminoacyl-tRNA. Used for CAP atypicals, rickettsial infections, acne, malaria prophylaxis. Photosensitivity; tooth discoloration in children <8.

PK: the intravenous row had no intravenous arm in its only citation and is re-sourced to PMID:2729939, six healthy males on a 200 mg infusion, verbatim "the half-life of intravenous doxycycline was shortened from 16.2 +/- 2.6" in the antacid-free arm. The oral half-life is corrected 17 -> 16.6 h, the figure its own paper states. ka 1.5 /h is a clean Tmax collision, that paper time to peak being 1.47 h. V 50 L and F 0.93 dropped as unsourced, which leaves both to the resolver defaults.

Pharmacokinetics

• Oral — t½ 16.6 h
• IV — t½ 16.2 h · F 100%

Sources: PMID:2080940, PMID:2729939