Drospirenone

hormone · renal · reproductive · Oral

Drospirenone, a hormone. Spironolactone-derived progestin — anti-mineralocorticoid + anti-androgenic activity makes it preferred in patients with… Oral half-life 30 h.

Spironolactone-derived progestin — anti-mineralocorticoid + anti-androgenic activity makes it preferred in patients with PCOS, premenstrual dysphoria, hirsutism. Hyperkalemia risk with renal impairment + ACEi. Slightly higher VTE signal than older progestins.

Pharmacokinetics

• Oral — t½ 30 h · F 76% · ka 2.3 h⁻¹ · Vd 280 L

Sources: PMID:11245553