DSIP

peptide · nervous · endocrine · Subcutaneous · Intranasal

DSIP, a peptide. Isolated by Schoenenberger + Monnier (1977) from cerebral blood of rabbits in the 'delta-sleep' state, but never reliably replicated as a…

Isolated by Schoenenberger + Monnier (1977) from cerebral blood of rabbits in the 'delta-sleep' state, but never reliably replicated as a single-molecule hypnotic in humans. Proposed mechanism remains obscure — possible somatostatin-receptor activity. Western clinical trials have been mostly negative; Russian / Eastern European use continues.

Native DSIP plasma half-life is very short (~7-15 min in dog; Kato 1984) — peptide is rapidly hydrolyzed by plasma peptidases. SC F assumed ≈1.0 for direct depot absorption; IN F is conservative 5% reflecting typical small-peptide nasal bioavailability. Curves are approximate — no human PK studies published; values are textbook ranges anchored to Kato's canine MCR study.

Sources: PMID:6379493, PMID:3768731, PMID:3550726