Dutasteride
Dutasteride, a hormone. Inhibits both type I and type II isoforms of 5α-reductase, preventing conversion of testosterone to dihydrotestosterone… Oral half-life 35 d.
Inhibits both type I and type II isoforms of 5α-reductase, preventing conversion of testosterone to dihydrotestosterone (DHT). Reduces serum DHT by >90% (vs ~70% for finasteride which only blocks type II). Used for benign prostatic hyperplasia and androgenic alopecia.
ABSORPTION-RATE PROVENANCE: this value was derived by inverting the one-compartment peak-time relation in 2026-05-26-wave25-ka-from-tmax.ts, whose header claimed every peak time was verbatim from a primary human study. ALL FORTY-FOUR ENTRIES HAVE NOW BEEN CHECKED AND TWENTY-EIGHT FAIL. This one fails because the cited abstract states no peak time at all, only that fed volunteers showed a higher one. It is DISCLOSED RATHER THAN DELETED: a midpoint of a narrow range is usually inside the true spread, and removing it would fall back on the solver default of 1.0 per hour, which is worse for most of these records.
Pharmacokinetics
- Oral — t½ 35.0 d · F 60% · ka 3.56 h⁻¹ · Vd 245 L
Related compounds
- Finasteride — warn
Sources: PMID:10073740, PMID:34690761