Eluxadoline

pharmacological · nervous · digestive · Oral

Eluxadoline. Mixed μ + κ-opioid agonist + δ-opioid antagonist — gut-locally-restricted (poor systemic absorption). Approved for IBS-D. Pancreatitis +…

Mixed μ + κ-opioid agonist + δ-opioid antagonist — gut-locally-restricted (poor systemic absorption). Approved for IBS-D. Pancreatitis + sphincter-of-Oddi spasm risk → contraindicated post-cholecystectomy.

Sources: PMID:28674470, PMID:25491493