Eszopiclone

sleep · nervous · Oral

Eszopiclone, a sleep compound. S-enantiomer of zopiclone. GABA-A PAM with slightly less α1 selectivity than zolpidem — longer t½ → better… Oral half-life 5.5 h.

S-enantiomer of zopiclone. GABA-A PAM with slightly less α1 selectivity than zolpidem — longer t½ → better sleep-maintenance (vs zolpidem's sleep-onset).

Pharmacokinetics

• Oral — t½ 5.5 h · F 80% · ka 3.251 h⁻¹ · Vd 90 L

Sources: PMID:1684924, PMID:18973287, PMID:9951403