Etomidate
Etomidate. Imidazole GABA-A positive allosteric modulator — induction agent of choice in hemodynamically unstable patients (preserves blood pressure… IV half-life 4 h.
Imidazole GABA-A positive allosteric modulator — induction agent of choice in hemodynamically unstable patients (preserves blood pressure better than propofol). Single-dose adrenal suppression via 11β-hydroxylase inhibition; not used for ICU infusion.
DOSE CORRECTED FROM A PER-KILOGRAM VALUE STORED AS AN ABSOLUTE ONE. The IV block read {"min":0.2,"max":0.4,"typical":0.3,"unit":"mg"} — those are mg/kg, not mg, and `doses` admits only absolute mg/g/mcg/IU, so occupancy was being judged at about a seventieth of a real dose. Label verbatim: "The dose for induction of anesthesia in adult patients and in pediatric patients above the age of ten (10) years will vary between 0.2 mg/kg and 0.6 mg/kg of body weight". At the 70 kg reference that is 14-42 mg, typical 21 mg — ARITHMETIC, mg/kg x 70 kg. Source: Amidate (etomidate) injection, DailyMed set id b7ed5bf8-ba75-44dc-8f81-96b4ad5766be, v27 published 2026-05-25. THE TYPICAL IS NOT THE LABEL’S: it states a range and no single figure, so 0.3 mg/kg is kept from the old row as the conventional induction dose INSIDE that range, and the stored max rises from the old 0.4 to the label’s 0.6. FOUND BY `occupancy.ts`: nothing reading one field at a time can see this, because every number in the row is individually well-formed.
Sources: PMID:455872