Etoricoxib
Etoricoxib. Selective COX-2 inhibitor — same class as celecoxib with greater COX-2 selectivity. Approved in EU + many countries (not FDA-approved… Oral half-life 22 h.
Selective COX-2 inhibitor — same class as celecoxib with greater COX-2 selectivity. Approved in EU + many countries (not FDA-approved due to CV concerns). Hypertension + MI signal at chronic high doses.
PK: BOTH OCCUPANCY ROWS ARE GENUINE HUMAN WHOLE-BLOOD ASSAYS AND THEIR FREE-FRACTION EXEMPTION IS CORRECT — the question that produced a live 333x error on diclofenac. Verbatim: "Etoricoxib selectively inhibited COX-2 in HUMAN WHOLE BLOOD ASSAYS in vitro, with an IC(50) value of 1.1 +/- 0.1 microM for COX-2 ... compared with an IC(50) value of 116 +/- 8 microM for COX-1", and both conversions check exactly. The cited PK paper reports only geometric mean ratios and supports none of the four stored values, but UNLIKE MOST SUCH CASES IN THIS BATCH every value is verbatim-sourceable elsewhere and the set survives the arithmetic: implied clearance 3.78 L/h against a measured intravenous 3.42, an 11% agreement, so the stored volume is a real intravenous-anchored figure rather than an orphaned population estimate. A RESIDUAL IS RECORDED AS IRREDUCIBLE: the predicted peak is 3.3x below observation, the same two-compartment signature seen on nimodipine, and matching it would require a volume that breaks the verified clearance. The previously cited paper stays as a legitimate interaction citation. One prose defect: the effect-compartment note claims an oral Tmax of about 1 h where the observed value is 2.6-3.3 h. PK: THE STORED ABSORPTION RATE WAS THE SOLVER DEFAULT WEARING A CITATION. A ka of 1.0/h is exactly what resolvePk substitutes when the field is ABSENT, and no source on this record states one. Removing it is NUMERICALLY A NO-OP — the resolver supplies the identical number — so no curve moves; what changes is that the record stops asserting an absorption rate it never measured. This is the same shape already found on a volume of 35 L, which is likewise the default at the seventy-kilogram reference. THE WIDER DEBT IS LEFT ALONE ON PURPOSE: twelve values account for 152 of the 276 authored absorption rates, but the other eleven are NOT the default, so deleting those would move their curves rather than leave them, which is the error this audit spent a batch documenting.
Pharmacokinetics
- Oral — t½ 22 h · F 100% · Vd 120 L
Sources: PMID:18777173, PMID:11160644, PMID:12638395, PMID:12527704