Famciclovir
Famciclovir. Diacetyl-6-deoxy-penciclovir prodrug — converted to penciclovir, which is phosphorylated by viral thymidine kinase (HSV / VZV) to… Oral half-life 2.2 h.
Diacetyl-6-deoxy-penciclovir prodrug — converted to penciclovir, which is phosphorylated by viral thymidine kinase (HSV / VZV) to triphosphate competitive-substrate / chain-terminator. Same indications as valacyclovir; alternative when patient tolerance differs.
PK: real-PMID zero-content, and EVERY VALUE HERE DESCRIBES PENCICLOVIR, not famciclovir — the parent is a diacetyl ester prodrug that is not the measured species. Half-life corrected 2.5 -> 2.15 h (PMID:8162668, nine healthy subjects on 500 mg orally); V 105 L is 1.5 L/kg measured after INTRAVENOUS PENCICLOVIR (PMID:1336464, fifteen subjects), so it is a true volume that pairs safely with a bioavailability; F 0.77 is retained but is REVIEW-GRADE only (PMID:8876860). ka 1.4 /h dropped. penciclovir is still not a slug in this registry, so the analyte the numbers describe cannot yet be named as its own record. MASS: the stored molecular weight described the PARENT while pk_analyte declares the metabolite, so the one field that must name a single species named the wrong one. LATENT RATHER THAN LIVE — this record carries no occupancy rows and is no other record interaction perpetrator — but it is one authored edge away from being live, because both consumers of the field (the micromolar-to-mass conversion for a kinetics edge, and the affinity the app renders from a stored occupancy concentration) want the species that actually circulates, which is the species pk[] already describes.
Pharmacokinetics
- Oral — t½ 2.1 h · F 77% · Vd 105 L
Sources: PMID:7738216, PMID:8162668, PMID:1336464, PMID:8876860