Fluphenazine
Fluphenazine. High-potency phenothiazine (typical) antipsychotic; predominantly a D2 antagonist, also blocks 5-HT2A. Oral form has very low… Oral half-life 16 h.
High-potency phenothiazine (typical) antipsychotic; predominantly a D2 antagonist, also blocks 5-HT2A. Oral form has very low bioavailability (~3%, heavy first-pass); long-acting decanoate depot dosed q2–5 weeks.
PK: TWO VALUES VERIFY AND THE VOLUME IS REFUTED TWO WAYS. F 0.027 is verbatim and is correctly the IMMEDIATE-RELEASE figure ("2.7% for the immediate release formulation and 3.4% for the slow release"), not the slow-release value and not a midpoint; the oral half-life of 16.4 h is verbatim and correctly the mean rather than the adjacent standard deviation of 13.3. V 1500 L is in no abstract and fails arithmetic twice over: the volume reproducing its own paper "Cmax 2.3 ng/mL at tmax 2.8 h" is about 125 L, so the model runs TWELVE TIMES LOW, and at steady state it puts the average concentration at or below the bottom of the therapeutic window this record other citation defines. IT IS RETAINED ONLY BECAUSE THE RESOLVER DEFAULT WOULD BE FORTY-FOLD WORSE, and no replacement is invented — a volume computed from this record own numbers is precisely the defect being hunted. ka 1.25 is a BACK-DERIVATION, reproducing that same 2.8 h peak exactly. THE DEPOT ROUTE IS REMOVED: its half-life was the oral value copied across, against a citation stating the opposite — "a long half-life measurable in MONTHS rather than weeks" — and its release duration appears nowhere.
Pharmacokinetics
- Oral — t½ 16.4 h · F 3% · Vd 1500 L
Sources: PMID:8911886, PMID:6787637, PMID:2286711, PMID:17826096, PMID:12629531