Fluticasone

pharmacological · respiratory · endocrine · digestive · immune-hematologic · Inhaled · Intranasal

Fluticasone. Inhaled / intranasal corticosteroid — high topical glucocorticoid receptor potency; near-zero systemic bioavailability after… Inhaled half-life 8 h.

Inhaled / intranasal corticosteroid — high topical glucocorticoid receptor potency; near-zero systemic bioavailability after inhalation due to first-pass metabolism. First-line maintenance therapy for asthma + allergic rhinitis. CYP3A4 substrate (ritonavir DDI causes systemic Cushing's).