Galantamine

nootropic · nervous · Oral

Galantamine, a nootropic. Phenanthrene-class AChE inhibitor + nicotinic ACh receptor positive allosteric modulator. Naturally derived from… Oral half-life 5.7 h.

Phenanthrene-class AChE inhibitor + nicotinic ACh receptor positive allosteric modulator. Naturally derived from Galanthus / Lycoris bulbs. Dual mechanism — ACh elevation plus nAChR sensitization — distinguishes it from donepezil/rivastigmine.

Pharmacokinetics

• Oral — t½ 5.7 h · F 100% · Vd 175 L

Sources: PMID:1914378