GB-115
GB-115, a peptide. Experimental cholecystokinin-related dipeptide studied in animal models and in a small clinical anxiety study. A clinical report describes it as a…
Experimental cholecystokinin-related dipeptide studied in animal models and in a small clinical anxiety study. A clinical report describes it as a cholecystokinin receptor blocker.
PK: The supplied list also names a nasal spray; no intranasal PK has been established in this entry. PMID:17886432 identifies an L-tryptophan derivative, while PMID:21476266 describes GB-115 with D-tryptophan; resolve this discrepancy before asserting stereochemistry. PK: PMID:27017703 compared oral crystalline and micronized GB-115 in rats and reported better bioavailability for the micronized material, but its abstract gives no model-ready PK values. PMID:31626171 describes a 31-patient anxiety study using 1 mg tablets and reports 6 mg/day; this is a study result, not a general dosing recommendation.
Sources: PMID:17886432, PMID:24130989, PMID:31626171, PMID:27017703