Gentamicin
Gentamicin. Aminoglycoside — binds bacterial 30S ribosome at A-site, causes misreading + premature chain termination.… Intramuscular half-life 1.9 h.
Aminoglycoside — binds bacterial 30S ribosome at A-site, causes misreading + premature chain termination. Concentration-dependent killing → once-daily extended-interval dosing. Nephrotoxicity + ototoxicity (cochlear + vestibular) require trough monitoring + audiometry.
PK: Merritt 1993 (PMID:8361865), 5 healthy men dosed on LEAN body weight, verbatim "beta half-life (112, 115 min)" and "volume of distribution (0.201, 0.184 L/kg)" — the normobaric arm gives 115 min (1.92 h) and 0.184 L/kg, which is 12.9 L at 70 kg. The stored 2 h and 14 L were roundings of the other arm. The IM row previously carried a half-life its own paper never reports and a ka of 2.33 /h matching nothing in it; that paper (PMID:3396458) supports only that IM bioavailability "was complete and did not differ from control values". CAVEATS: gentamicin is renally cleared, so a fixed half-life is valid only at normal renal function; and the volume is body-composition dependent (PMID:712111), so it should be read per kilogram rather than as a fixed 12.9 L.
Pharmacokinetics
- IV — t½ 1.9 h · F 100% · Vd 12.9 L
- Intramuscular — t½ 1.9 h · F 100%
Sources: PMID:8361865, PMID:712111