GHRP-6
GHRP-6, a peptide. First-generation GHSR-1a agonist. More potent appetite-stimulatory effect than GHRP-2 or ipamorelin — useful property… Subcutaneous half-life 2.5 h.
First-generation GHSR-1a agonist. More potent appetite-stimulatory effect than GHRP-2 or ipamorelin — useful property when cachexia is a therapeutic target, a nuisance otherwise. Moderate cortisol/prolactin rise.
PK: Cabrales 2013 (PMID:23099431), 9 healthy male volunteers, verbatim "the distribution and elimination half-life of GHRP-6 were 7.6 +/- 1.9 min and 2.5 +/- 1.1h, respectively". ROUTE CAVEAT: that study dosed a single IV bolus; the value is a systemic elimination half-life so it transfers, but no SC study exists for this peptide. F 0.7 dropped 2026-09-06 — it appears in no source. The only subcutaneous bioavailability on record is animal and spans two species, 89-103% in rat and dog (PMID:8149896), which cannot be reduced to one number.
Pharmacokinetics
- Subcutaneous — t½ 2.5 h
Sources: PMID:23099431, PMID:9879640