Ginsenoside Rg1

adaptogen · nervous · cardiovascular · digestive · Oral

Ginsenoside Rg1, an adaptogen. Protopanaxatriol-class ginsenoside (sugars at C6 and C20). Of the dominant ginsenosides in Panax ginseng, Rg1 is the lead candidate for…

Protopanaxatriol-class ginsenoside (sugars at C6 and C20). Of the dominant ginsenosides in Panax ginseng, Rg1 is the lead candidate for cognitive / neuroprotective endpoints: induces hippocampal BDNF, inhibits NMDA-mediated excitotoxicity, and activates the PI3K/AKT survival pathway. Oral bioavailability in rats ~6–18% (P-gp efflux limits absorption; gut microbiota hydrolyses Rg1 to the aglycone F1 / protopanaxatriol, which reaches systemic circulation). Rg1 itself crosses BBB at low ng/mL. NO-mediated vasodilation also Rg1-attributed in some assays.

Sources: PMID:39756553