Ginsenoside Rg3

adaptogen · digestive · Oral

Ginsenoside Rg3, an adaptogen. Protopanaxadiol-class ginsenoside with one sugar at C3; produced by steaming raw ginseng (red ginseng contains… Oral half-life 4.9 h.

Protopanaxadiol-class ginsenoside with one sugar at C3; produced by steaming raw ginseng (red ginseng contains ~5–10× more Rg3 than white ginseng via partial dehydration of Rb1/Rb2/Rc). 20(S)-Rg3 is the clinically-studied stereoisomer. Primary research interest is anti-angiogenic / anti-metastatic oncology activity — inhibits VEGF signalling, matrix metalloproteinases, and EMT. Zhao 2016 Phase-I in healthy Chinese volunteers characterised single- and multi-dose PK: dose-proportional kinetics, t½ ~25 h, no accumulation on chronic dosing. Approved as Shenyi capsule adjuvant in China for NSCLC and hepatocellular carcinoma.

Pharmacokinetics

• Oral — t½ 4.9 h · F 5% · ka 2.48 h⁻¹ · Vd 1025 L

Sources: PMID:26470874, PMID:35111231, PMID:12580081